White matter abnormalities and illness severity in major depressive disorder
نویسندگان
چکیده
منابع مشابه
White matter abnormalities and illness severity in major depressive disorder.
BACKGROUND White matter abnormalities have been implicated in the aetiology of major depressive disorder; however, the relationship between the severity of symptoms and white matter integrity is currently unclear. AIMS To investigate white matter integrity in people with major depression and healthy controls, and to assess its relationship with depressive symptom severity. METHOD Diffusion ...
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Prefrontal impairments have been hypothesized to be most strongly associated with the cognitive and emotional dysfunction in depression. Recently, white matter microstructural abnormalities in prefrontal lobe have been reported in elderly patients with major depressive disorder (MDD) using diffusion tensor imaging (DTI). However, it is still unclear whether the same changes exist in younger pat...
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OBJECTIVE The aim of this study was to explore the microstructural integrity of whole-brain white matter by diffusion tensor imaging in first-episode, treatment-naive young adults with major depressive disorder. METHOD Diffusion tensor imaging scans were obtained from 14 first-episode, treatment-naive young adult patients with major depressive disorder and 14 healthy comparison subjects. A vo...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 2012
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.bp.111.100594